Triglyceride Synthesis in Epididymal Adipose Tissue
نویسندگان
چکیده
منابع مشابه
Reassessing triglyceride synthesis in adipose tissue.
The synthesis and breakdown of triglycerides in adipose tissue and muscle is a crucial element of energy metabolism because it ensures that adequate fuel is available during starvation. Triglyceride turnover determines the availability of fatty acids for utilization by mammalian tissues, and any dysfunction in this process can lead to alterations in glucose metabolism, insulin resistance and ty...
متن کاملThe Regulation of Triglyceride Synthesis and Fatty Acid Synthesis in Rat Epididymal Adipose Tissue EFFECTS OF INSULIN, ADRENALINE AND SOME METABOLITES IN VITRO
1. Adipose tissues from rats fed a balanced diet were incubated in the presence of glucose (20mM) with the following additions: insulin, anti-insulin serum, insulin+ acetate, insulin +pyruvate, insulin+ lactate, insulin+phenazine methosulphate, insulin +oleate +albumin, insulin +adrenaline +albumin, insulin+ 6-N-2'-O-dibutyryl 3': 5'-cyclic AMP +albumin. 2. Measurements were made ofthe whole ti...
متن کاملThe regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Effects of altered dietary and hormonal conditions.
1. Epididymal adipose tissues obtained from rats that had been previously starved, starved and refed a high fat diet for 72h, starved and refed bread for 144h or fed a normal diet were incubated in the presence of insulin+glucose or insulin+glucose+acetate. 2. Measurements were made of the whole-tissue concentrations of hexose phosphates, triose phosphates, glycerol 1-phosphate, 3-phosphoglycer...
متن کاملEffects of fluoroacetate and (-)-hydroxycitrate on fatty acid synthesis in rat epididymal adipose tissue [proceedings].
Pads were preincubated for 30min at 37°C in bicarbonate-buffered medium (Krebs & Henseleit, 1932) containing glucose (1 1 mM) and, whereappropriate, fluoroacetate(1 mM). For the assay of enzyme activities and tissue citrate concentration, the pads were transferred to fresh medium containing glucose ( l l m ~ ) and additions of insulin ( 5 munits/ml), fluoroacetate (1 mM) and (-)-hydroxycitrate ...
متن کاملHormonal regulation of acetyl-CoA carboxylase in epididymal adipose tissue.
Treatment of rat epididymal adipose tissue with insulin for a few minutes leads to a substantial increase in the rate of fatty acid synthesis, which is explained in part by rapid activation of the cytoplasmic enzyme acetyl-CoA carboxylase (Denton, 1975; Denton et al., 1977; Brownsey & Denton, 1979). The effects of insulin on fatty acid synthesis are opposed by adrenaline, but the changes in kin...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m808668200